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Liverpool submitted an offer on Friday that totaled $153 million (£113M) — around $135M (£100M) up front and up to around $18M (£13M) in add-ons.
Leverkusen though is still holding out for more money, although it would appear that a move to Anfield - which Wirtz is understood to be keen on - is still likely.
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According to the Daily Mail, the Bundesliga side is resigned to losing Wirtz, and has now lowered its original asking price of $171M, and is now holding out for around $160M.
Having had its latest offer turned down, Liverpool is expected to make a final offer that will reach that figure within the next 24 hours.
Despite the ongoing saga around his future, Wirtz’s current focus remains on his international duties, with Bild reporting that Leverkusen did not ask the DFB - Germany’s governing body - to rest him for Sunday’s third-place play-off against France in the UEFA Nations League.
Florian Wirtz in action for Germany in the UEFA Nations League third-place play-off against France
What’s more, Wirtz was handed another start by Julian Nagelsmann, having also played every minute of the semi-final defeat to Portugal on Wednesday.
That decision may not go down too well with Liverpool and its fans, given the risk of Wirtz picking up an injury in what is an unnecessary game.
Although the concept of a 'final offer' may leave some supporters worried, it is suggested that all parties are confident a deal can be struck, with Wirtz apparently "desperate" to move to Anfield.
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The 22-year-old has dropped a couple of hints recently that he is set to join former teammate Jeremie Frimpong on Merseyside this summer after responding angrily to speculation that he wanted Alexis Mac Allister's No.10 shirt, while also delivering a telling nod after being asked whether he was looking forward to joining Liverpool.
Given his desire to join the Reds, Leverkusen is not planning on standing in his way, as long as they receive what they consider to be a fair price.
Liverpool.com says: Liverpool would have every right to not be happy with Wirtz starting again for Germany against France today.
A third-place play-off in the Nations League is completely meaningless, and yet there is now the added risk of him picking up an injury before what would be a record transfer.
Fingers crossed he comes through that game unscathed, and that Liverpool gets a deal over the line soon.