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Liverpool and Manchester City will take on Real Madrid, while Chelsea face Barcelona after Champions League sides discovered their league phase opponents.
Arsenal also take on Harry Kane's Bayern Munich.
Fellow English sides Tottenham and Newcastle were drawn against current holders Paris Saint-Germain.
All six Premier League clubs involved in the Champions League will play eight league phase games, home and away, between September 2025 and January 2026.
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Who will the English clubs face?
Chelsea: Barcelona (H), Bayern Munich (A), Benfica (H), Atalanta (A), Ajax (H), Napoli (A), Pafos (H), Qarabag (A).
Liverpool: Real Madrid (H), Inter (A), Atletico Madrid (A), Frankfurt (A), PSV (H), Marseille (A), Qaraba? (H), Galatasaray (A).
Man City: Borussia Dortmund (H), Real Madrid (A), Leverkusen (H), Villarreal (A), Napoli (H), Bodø/Glimt (A), Galatasaray (H), Monaco (A).
Also See:
Arsenal: Bayern Munich (H), Inter (A), Atleti (H), Club Brugge (A), Olympiacos (H), Slavia Praha (A), Kairat Almaty (H), Athletic Club (A).
Tottenham: Borussia Dortmund (H), Paris (A), Villarreal (H), Frankfurt (A), Slavia Praha (H), Bodø/Glimt (A), Copenhagen (H), Monaco (A).
Newcastle: Barcelona (H), Paris (A), Benfica (H), Leverkusen (A), PSV (H), Marseille (A), Athletic Club (H), Union SG (A).
How does the Champions League league phase work?
The new format, which began in the 2024/25 season, sees teams play eight matches in a league phase that has replaced the group stage.
Teams now play fixtures against eight different sides - two teams from Pots 1, 2, 3 and 4.
Tottenham's reward for winning the Europa League is a place in the 20525/26 Champions League league phase
Who qualifies for the knockout rounds?
The top eight sides in the league will qualify automatically for the round of 16, while teams finishing 25th or lower are eliminated and do not drop into the Europa League.
The teams finishing in ninth to 24th place compete in a two-legged knockout phase play-off
Teams finishing between ninth and 16th are seeded, meaning they will face a team in 17th-24th with the return leg at home.
The eight clubs who win their knockout-phase play-off each meet one of the seeded top-eight finishers in the league phase table for a place in the quarter-finals.
Champions League league phase match dates and schedule
Matchday 1: September 16-18
Matchday 2: September 30-October 1
Matchday 3: October 21/22
Matchday 4: November 4/5
Matchday 5: November 25/26
Matchday 6: December 9/10
Matchday 7: January 20/21
Matchday 8: January 28
Champions League knockout phase match dates and schedule
The draw for the two-legged knockout-phase play-offs takes place on January 30 2026.
The draws for the round of 16, quarter-finals and semi-finals takes place on February 27.
Knockout phase play-offs: February 17/18 and 24/25
Round of 16: March 10/11 and 17/18
Quarter-finals: April 7/8 and 14/15
Semi-finals: April 28/29 and May 5/6
Final: May 30
When are where is the final?
The final will take place at the Puskas Arena in Hungary, Budapest on May 30 2026.