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With four games still to play, the Reds have the chance to really open up the gap on Arsenal and pile the misery on Mikel Arteta's side.
They face a Chelsea side coming off the back of a resounding win in the UEFA Conference League, with Enzo Maresca's team all but in the final already after a 4-1 win at Djurgarden.
The Blues though are eyeing up a place in the Champions League next season, and they may well have been helped by Liverpool getting the title wrapped up early.
Slot has confirmed he will rotate his squad over the remaining fixtures, meaning some of the Reds' fringe players could get a start at Stamford Bridge today.
Follow all the action as Liverpool takes on Chelsea with our live updates below.
We'll bring you all the team news before kick-off at Stamford Bridge.
Chelsea 3-1 LiverpoolKEY EVENT
GOAL - Palmer seals it
Palmer makes no mistake from the spot as he fires past the outstretched arm of Alisson, and that'll confirm Chelsea's win.
Chelsea 2-1 LiverpoolJames Findlater
Penalty to Chelsea
Quansah brings Caicedo down, and Chelsea has a chance to make it 3-1 from the spot.
Either way, that's probably game over...
Chelsea 2-1 LiverpoolJames Findlater
Time running out
We're into five minutes of stoppage time now, and Chelsea look as though they're just going to try and see this one out now.
Plenty of fouls and stoppages, making sure Liverpool can't get any time on the ball to try and find an equalizer.
Chelsea 2-1 LiverpoolKEY EVENT
GOAL!
Van Dijk scores!
Hello, Liverpool might just have a way back into this!
Virgil van Dijk heads home from a corner to halve the deficit!
Chelsea 2-0 LiverpoolJames Findlater
Substitution
Final change from Liverpool as Federico Chiesa comes on for Kostas Tsimikas - he's got that fifth appearance he needs to guarantee himself a medal now.
Chelsea 2-0 LiverpoolJames Findlater
Off the post!
Cole Palmer has been brilliant today, and he almost bags a goal as he sprints past Bradley and hits the post from a tight angle.
Chelsea 2-0 LiverpoolJames Findlater
Great save
Good save from Alisson to deny Sancho.
At the moment, it doesn't feel like a save that will make a huge difference, but there is still time for Liverpool to get something out of this game.
Chelsea 2-0 LiverpoolJames Findlater
Chance!
Tsimikas finds Salah at the back post, but the Egyptian directs his header wide as he tries to send the ball back across goal.
Chelsea 2-0 LiverpoolJames Findlater
Substitutions
Alexis Mac Allister and Dominik Szoboszlai are both on now, with Elliott and Endo coming off
Chelsea 2-0 LiverpoolJames Findlater
Chance
Well, that just about sumes Darwin Nunez up.
Salah picks him out with a dinked cross, it's a free header, and he gets it horribly wrong as it goes miles wide.
Chelsea 2-0 LiverpoolJames Findlater
Chance!
About as close as Liverpool has come all afternoon.
A dangerous cross from Gakpo out on the left, which Colwill just manages to get his head on and clear away for a corner.
Chelsea 2-0 LiverpoolJames Findlater
Yellow card
Quansah is the latest player in the book
Chelsea 2-0 LiverpoolJames Findlater
Substitutions
Jota and Alexander-Arnold off, Darwin Nunez and Conor Bradley on
Chelsea 2-0 LiverpoolKEY EVENT
GOAL - Chelsea doubles the lead
Van Dijk's attempted clearance comes off a player - looks like Quansah - and bounces into the goal.
Chelsea 1-0 LiverpoolJames Findlater
Yellow card
Trevoh Chalobah goes into the book after stopping Curtis Jones from taking a free-kick quickly
Chelsea 1-0 LiverpoolJames Findlater
Yellow card
Virgil van Dijk goes into the book after catching Lavia in a 50-50, with the Chelsea midfielder getting to the ball first before feeling the Liverpool captain's boot on his knee.
Chelsea 1-0 LiverpoolJames Findlater
Chance
Madueka dances toward the Liverpool penalty area and lays it off to Jackson, who snaps at the shot and doesn't get any power on it as it dribbles into Alisson's arms.
James Findlater
Back underway
Chelsea kick us off in the second half
James Findlater
Deja vu
There is a distinct feel of that Man City game back in 2020 about this one.
That's unbelievably lazy from the Chelsea striker.
Chelsea 1-0 LiverpoolJames Findlater
Off the bar!
A sustained spell of pressure from Chelsea as Liverpool struggles to clear its lines from back-to-back corners.
In the end, Caicedo tries to lift the ball into the box from the right, and in the process manages to hit the top of the crossbar.
Chelsea 1-0 LiverpoolJames Findlater
Liverpool looking rusty
Alexander-Arnold tries to find Salah in space, but the Egyptian's first touch lets him down.
More than a few Liverpool players looking a bit rusty so far, which is perhaps to be expected after the high of last week.
Chelsea 1-0 LiverpoolJames Findlater
Chance
Cody Gakpo charging down the left - it's a tight angle, and it proves probably too tight in the end as he fires it straight at Sanchez.
Chelsea 1-0 LiverpoolJames Findlater
Chance
Chelsea looks as though its in the mood - the Blues are on the attack again, with Madueke scuffing his effort just wide
Chelsea 1-0 LiverpoolKEY EVENT
GOAL - Chelsea takes the lead
Chelsea has a very early lead, and it's a well worked one as Enzo Fernandez finishes it off with a cooly taken finish
Chelsea 0-0 LiverpoolJames Findlater
On the attack
Liverpool on the attack early with some lovely stuff between Elliott and Salah on the right.
The latter tries to square it to a teammate from a tight angle, but Sanchez manages to pounce on it.
James Findlater
Kick-off
The Reds get us underway in the first half
James Findlater
Here come the players
Chelsea do indeed give a guard of honor to Liverpool's players - and the gesture is greeted by a round of boos from the home supporters.
Kick-off is just around the corner now...
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