FA Cup winners Crystal Palace twice came from behind to force the penalty shootout after 90 minutes and it was Palace who held their nerve better in the shoot out.
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The reds started brightly - Ekitike and Wirtz combining in the fourth minute for the Frenchman to take his debut goal with some skill - placed neatly into the corner past Dean Henderson.
Liverpool were the better side in the first half but it was the normally ever-reliable Virgil van Dijk who gave Palace the lifeline when he felled Ismaila Sarr.
The reds were more disjointed after the break, Ekitikie tired after he should have added a second - both him and Wirtz were ultimately replaced in the game.
Palace's penalties ultimately proved better - Salah skied his penalty in front of the Liverpool fans and Henderson saved fairly weak penalties from both Elliott and Mac Allister
VIDEO HIGHLIGHTS: Palace 2-2 Liverpool (3-2 pens)
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