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The Saints, on the other hand, will make their way to Anfield on Tuesday evening hoping to end a run of three games without a victory.Arne Slot's Premier League champions are looking like good value to retain their title and add even more trophies to their cabinet.
The Reds are already five points clear at the head of England's top flight and have long been tipped for a clean sweep of silverware this season.
This will be the third straight season in which Liverpool and Southampton, currently 19th in the Championship, have met in cup competition.
The Merseysiders knocked the south coast outfit out of the FA Cup fifth round in February 2024, then ousted them from last term's League Cup in the quarter-finals.
In fact, Liverpool are undefeated in their last nine meetings with Southampton and have won eight of those.
This is thanks to an ongoing rights partnership between the two broadcasters, which means many League Cup and Championship games will be shared between the two this season.
That's music to the ears of many fans without an active Sky Sports subscription.
In that vein, the Dutchman has already confirmed Dominik Szoboszlai, Mohamed Salah, Ryan Gravenberch, Ibrahima Konate and Virgil van Dijk will be rested after starting every game so far this term.
Alexander Isak made his Premier League debut for Liverpool in their 2-1 derby win over Everton at the weekend.
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