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Having drawn twice already this season, Chelsea has fallen behind the leaders in the Premier League title race.
But it is still four points clear of Manchester United heading into the clash between the pair at Old Trafford.
Enzo Maresca's men were beaten by Bayern Munich in the Champions League midweek and are playing catch-up domestically at this early stage, but the Spaniard is not under pressure.
Manchester United has beaten Burnley this season, but was comfortably beaten in the Manchester derby last week.
In the UK, the Manchester United vs Chelsea game will be shown live on Sky Sports Premier League and Sky Sports Main Event.
In the US, it will be on Peacock and can be streamed via NBC.
Mason Mount and Matheus Cunha are both available again for Manchester United after they missed the defeat to Manchester City at the Etihad Stadium.
Manchester United owner Jim Ratcliffe visited Amorim at the training ground this week, but there is no suggestion that he is set to fire the Portuguese at this stage