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Isak has also been instrumental in helping the club finish fourth, seventh and fifth in the Premier League over the past three seasons, not to mention scoring the winner in the 2025 Carabao Cup final.
However, the 25-year-old's future on Tyneside has been clouded in speculation this summer, as the Swede made clear he wished to explore his options away from Newcastle, with Premier League champions Liverpool the only realistic destination for Isak at present.
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According to Berbatov, who faced a similar situation when he left Tottenham Hotspur to play for Manchester United back in 2008 in a £30.75million move, Isak will have plenty on his mind, and he knows just what the player is going through.
Speaking exclusively to Mirror Football, the LiveScore and LiveScore Bet European Brand Ambassador said: "I've been there.
I've been in that situation as well, so for a striker or any star player of a team at one point or another, more often than not, it's going to come down to this.
"Him wanting to leave if a bigger club comes after him.
Giving him opinions, guidance maybe, and it's going to come to a point, I don't know if that's the point now that we're seeing, where you say to the club, 'Look I've given enough, now it's time to move on.'
"The club's maybe not going to react well, especially if they don't have the replacement in hand, so now they need to react quickly.
It's never a good thing, it's never a good thing and it pains me to see stuff like this."
The now 44-year-old also highlighted how he faced a similar scenario when he joined United from Spurs in 2008, given how highly thought of he was at White Hart Lane at the time.
Of course, the fans, some of them will be okay, the majority of them probably will not understand because this is the star player, the player who scored goals, the player who Newcastle gave the opportunity to show what he can do.
"So it's never an easy thing and it's just a situation where honestly you don't want to be in.
So it's about finding the right answer."
Liverpool have already approached Newcastle United for Isak with a bid of £110m, only to see it quickly rebuffed due to the Magpies' £150m valuation of their star man.
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