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However, the curtain raiser against Bournemouth marks a huge change from something that's been an almost constant at Anfield for over half a century, as it's the first game that won't be sound-tracked by George's distinctive voice.
Hearing the 79-year-old when the Reds play at home is something as associated with the matchday experience as a pint in The Sandon or a walk across Stanley Park.
He told the ECHO in an exclusive interview how he has mixed feelings about his return to the terraces.
He said: "It's going to be weird.
Obviously, I've been to European away games and Wembley, but this will be a whole new ball game for me."
He laughed: "I said to my wife, 'I hope I get on with the guys on either side.
It's the way we treat other people and the way we welcome people."
George has never looked back from his first announcement at Anfield - and his love for the club meant he juggled his duties in the gantry with full time work in a 9 - 5 IT job.
The "Voice of Anfield" is entwined with the story of Liverpool and has witnessed some of the most historic moments in the club's history during his stint as stadium announcer.
He credits the 4 - 0 win over Barcelona in 2019 as the greatest game during his tenure and doesn't hesitate when he's asked to name his favourite player.
This would be as good a time as any because you're at the top of your game and Liverpool have just won the league'."
He added: "The worst part was on the Friday when the club announced it at 4pm on their website.