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Joel Matip has yet to train with his teammates ahead of Sunday's crunch encounter between Liverpool and Manchester United.
Rhys Williams (19) and Nat Phillips (23) have played a total of 390 Premier League minutes between them, while either would be seen as a risk - if an unavoidable one given the circumstances - against a side as dangerous as United.
The Red Devils leapfrogged the Premier League title holders into first place on Tuesday night with a 1-0 win over Burnley.
Aside from Matip, the Reds still have Kostas Tsimikas and Diogo Jota ruled out for the match, as well as Gomez and Van Dijk, while Naby Keita is another doubt.
Matip has, of course, been Liverpool's only real senior centre-back option for much of this season, after both Virgil van Dijk and Joe Gomez suffered serious knee injuries last year.
Jurgen Klopp will clearly be keen to have as many players available as possible for the derby clash, but Matip remains a doubt with just days to go.
Fabinho has deputised at the back with aplomb but the potential absence of Matip creates a selection dilemma for Klopp ahead of arguably his biggest league game of the season so far.
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