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If the deal is finalised, it would be a major boost for a side that finished 15th in the Premier League last season - and another frustrating blow for Newcastle, who have already missed out on several prominent forward options this window, including Hugo Ekitike, who joined Liverpool from Eintracht Frankfurt last month.
But the impact of this transfer won't be limited to Manchester United and Newcastle - Liverpool could also feel the ripple effects.
If and when Sesko leaves, Leipzig will be in the market for attacking reinforcements and are expected to act quickly.
High on their shortlist is Liverpool midfielder Harvey Elliott, whose future at Anfield is uncertain after being used sparingly last season.
However, Liverpool won't part ways with him easily.
Both Xavi Simons (L) and Benjamin Sesko (R) are expected to leave RB Leipzig this summer(Image: Getty Images)
According to The Athletic, the Reds have asked for a minimum of £40m with a buy-back clause included.
In June, Elliott acknowledged his concern over "wasting years of my career" after starting only seven times across all competitions last season.
Harvey Elliott could leave Liverpool this summer after spending much of last season on the bench(Image: 2025 Robbie Jay Barratt - AMA)
"It's just a situation that me and the team have to have a conversation about because I'm coming into an age now where I'm 22, I'm going to be 23 next season," Elliott said.
But as I said, most importantly, it's just about what's best for my career."
Jurgen Klopp made no secret of his admiration for Harvey Elliott(Image: Getty Images)
Elliott had once been tipped for a key role at Liverpool.
He was probably our best player, right wing, right midfield, all these kinds of things."
A move to Leipzig could reunite Elliott with Klopp in a new way.
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