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Recent comments made by Real Madrid striker Karim Benzeme could hint at a possible second leg advantage for Liverpool.
The La Liga title is still to be decided, with both Real and Barca chasing leaders Atletico Madrid going into this weekend’s fixture.
Should Real win that game, they would go level on points with their city rivals at the top of the table, who take on Real Betis on Sunday.
Jurgen Klopp may be in a slightly better position to rotate and mix up his side for the weekend's action before the crunch Champions League clash on Wednesday.
Before then is a Premier League clash at home to Aston Villa - while Madrid have the small matter of El Clasico against Barcelona.
However, Real have a title on the line and a defeat to Barca in El Clasico could spell the end for their hopes of winning a 35th league crown.
“In my opinion, El Clasico is the greatest game in the world,” said Benzema, speaking to AS.