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The Scotland international did not feature in the teams' Premier League season opener after a breakthrough in discussions and now a deal is all but done.
Doak, 19, spent last season on loan at Middlesbrough, where he recorded three goals and seven assists in an impressive stint before injury curtailed his 2024/25 campaign.
While the Anfield side have spent hefty fees on the likes of Florian Wirtz, the club will have raised £215m following Doak's exit.
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The ex-Celtic youngster follows the likes of Jarell Quansah, Luis Diaz and Darwin Nunez out of the door.
And such business leaves Liverpool primed to return for Alexander Isak if encouraged by the Magpies to do so.
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Isak was absent for Newcastle's opening match of the season against Aston Villa having not trained with the first team amid his stand off with the club over an exit.
Howe has indicated that he remains open to the striker's return despite the dispute.
Alexander Isak remains out of contention for Newcastle(Image: Getty Images)
Fans vented their feelings on Isak following the draw at Villa Park and criticised his stance.
"Nothing has changed - but the door is well and truly open (for Isak)," said Howe.
We would like a resolution, when I say we I am talking about myself and the ownership, the players we have, we need that clarity.
"This season, any Premier League season is hard enough, you don't need any type of distraction to swerve your thoughts and unbalance what we are doing.
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