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While a formal offer has not been made yet, Sky Sports News reported on Wednesday they had opened talks with the Bundesliga club for the striker after it was revealed on Tuesday they were expected to rival Newcastle for the striker.
Sky Sports News also understands Newcastle are aware of Liverpool's interest and are reviewing their options, with reports suggesting the Toon are now exploring a deal to sign Brentford's Yoane Wissa.
Liverpool have moved for Ekitike after being told Alexander Isak is not for sale in this window.
The Premier League champions have always been interested in Isak but it is understood Newcastle have no interest in selling their striker and value him at least at £150m.
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Watch the pick of Newcastle striker Alexander Isak's Premier League goals from this season including a stunner at home to Liverpool.
Sky Sports' Adam Bate:
When Hugo Ekitike was still a teenager at Stade Reims, the coaching staff prepared a development plan for him
He always wanted to be compared with the best ones."
Read more about Hugo Ekitike's rise here.
Sky Sports to show 215 live Premier League games from next season
Watch more Premier League matches on Sky Sports ever before with 215 games live of the 2025/26 Premier League season
From next season, Sky Sports' Premier League coverage will increase from 128 matches to at least 215 games exclusively live.
And 80 per cent of all televised Premier League games next season are on Sky Sports.
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