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The Reds' defeat to Everton in the Merseyside derby means it is three points adrift of Arsenal with four games to play.
The Gunners also boast a considerably better goal difference and Manchester City leapfrogged Liverpool into second by putting Brighton to the sword on Thursday night.
Liverpool's title rivals also face tricky away matches this weekend, with Arsenal having a north London derby against Tottenham and City travelling to Nottingham Forest.
But Jürgen Klopp's side has to win to put pressure on the top two.
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Klopp was without a number of key players against Everton and it told, with his side once again wasting a series of chances.
He was also unable to freshen up his attack in the closing stages of the game.
Here is the latest injury news from Anfield and when Liverpool fans can expect to see the sidelined players back in action ahead of the final four matches of the Klopp era.
Cody Gakpo
The Liverpool ace missed the Merseyside derby defeat to Everton, with he and his partner expecting a baby.
His manager is likely to provide an update when he speaks to the media in Friday's press conference.
Potential return date: West Ham or Tottenham (May 5).
Diogo Jota
Liverpool forward Diogo Jota picked up an injury at Fulham last weekend and also sat out the Everton defeat.
When I say two weeks, actually really it’s pretty much nothing but enough to not be available.”
Potential return date: Tottenham (May 5).
Conor Bradley
Liverpool expect defender Conor Bradley to be sidelined for another week after he suffered an ankle injury in the defeat to Crystal Palace.
Bradley underwent scans on the problem, which showed no serious damage, but enough to rule him out for a couple of weeks.
Klopp revealed that it was a similar issue to the one sustained by Ryan Gravenberch earlier in the campaign, which kept the Dutch midfielder out for a fortnight.
Potential return date: Tottenham (May 5).
Thiago Alcântara, Joël Matip and Ben Doak
Liverpool fans appear to have seen the last of Thiago and Joël Matip in a red shirt, with both players out of contract at the end of the season.
For more news relating to Everton, visit our sister site EFC Live.