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Or will he stick largely with big guns that have brought home the Premier League title?
Alisson Becker starts and Conor Bradley continues at right-back.
Ibrahima Konate and Virgil van Dijk partner at centre-back and I'm giving Andy Robertson the nod on the left side.
So the attacking midfielder starts as the most advanced with Ryan Gravenberch and Alexis Mac Allister patrolling further back.
My team (4-2-3-1): Alisson; Bradley, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Elliott, Gakpo; Diaz.
But so many of the most recent meetings between the teams have been closely-fought affairs and the Seagulls will be fired up given their season remains very much alive.
Slot, then, should go strong, with Alisson Becker in goal, Andy Robertson at left-back, and Ibrahima Konate partnering captain Virgil van Dijk at centre-back.
There is no question Conor Bradley starts at right-back over the departing Trent Alexander-Arnold
Given the reaction to his arrival off the bench against Arsenal last weekend, and the impact it had on the Anfield atmosphere, there must be a question now for Slot over whether Alexander-Arnold features in his final two matches for the club.
In midfield, Alexis Mac Allister returns alongside Ryan Gravenberch, while Harvey Elliott is given the chance to impress in front of the Reds' first-choice centre-midfield.
Cody Gakpo and Mohamed Salah are either side of him, with Luis Diaz in the centre-forward's position.
My team (4-2-3-1): Alisson; Bradley, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Elliott, Gakpo; Diaz
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