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Speaking following the 2-1 triumph over Everton, the Liverpool manager declared: "Yes, there will be a completely changed line-up."Article continues below ADVERTISEMENT
But which players will he introduce?
Liverpool Echo writers Paul Gorst, Theo Squires and Mark Jones have given their preferred selections.
Paul Gorst
Arne Slot has already revealed his hand for this encounter, confirming that numerous first-team stars will be absent when Liverpool launch their Carabao Cup journey.
Anticipate wholesale changes for this fixture.
The most fascinating aspect will be observing how those on the periphery seize the chance presented by Slot.
In my view, promising Italian centre-back Giovanni Leoni partners Joe Gomez in his preferred central defensive role, whilst Andy Robertson leads the team for the first occasion since becoming Van Dijk's deputy.
Jeremie Frimpong features down the right flank.
In the engine room, Wataru Endo earns a spot alongside Curtis Jones, with Trey Nyoni given his second successive start against Southampton in this tournament.
On the left flank, promising Rio Ngumoha starts, hoping to build on his impressive few months under Slot.
My team: Mamardashvili; Frimpong, Leoni, Gomez, Robertson; Endo, Jones; Chiesa, Nyoni, Ngumoha; Isak.
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Thus, it's an excellent opportunity for some of the Reds' fringe players to gain some valuable game time and demonstrate their abilities.
Giorgi Mamardashvili and Giovanni Leoni are both set to make their debuts in this match, with the young Italian paired with Joe Gomez at centre-back.
Curtis Jones is primed to be the first substitute as he recovers from injury following his return in the derby.
My team (4-2-3-1): Mamardashvili; Frimpong, Leoni, Gomez, Robertson; Endo, Nyoni; Chiesa, Wirtz, Ngumoha; Isak.
Mark Jones
The first Carabao Cup tie of the season is always an exciting event, isn't it?
Well, unless you're Manchester United that is.
We're set to see some fresh faces at Anfield this evening, players we haven't yet seen this season, and Arne Slot has made it clear that he's not just going to shuffle his pack, but choose a completely different deck entirely.
Giorgi Mamardashvili is set to make his debut in goal, and following Conor Bradley's bustling performance against Jack Grealish, the back four seems self-evident - Jeremie Frimpong, promising newcomer Giovanni Leoni, Joe Gomez and skipper Andy Robertson.
The real conundrum lies in the midfield selection.
I'd place him as the No.10 with Wataru Endo and Curtis Jones supporting him, but keeping Trey Nyoni in mind as the first substitute, possibly at half-time.
The logical front three would then comprise Federico Chiesa, Alexander Isak and Rio Ngumoha, with the 17-year-old ready to dazzle Anfield once more and Isak requiring some crucial game time.
An hour should suffice, before Jayden Danns is let loose on Southampton again.
My team: Mamardashvili; Frimpong, Leoni, Gomez, Robertson; Endo, Jones; Chiesa, Wirtz, Ngumoha; Isak.