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Arne Slot makes 11 changes to the Liverpool team that hosts Southampton in the Carabao Cup as Alexander Isak starts up top.
The £125m British transfer record signing has played around 100 minutes for club and country since May.
And having come off the bench for Saturday's 2-1 win over Everton in the Merseyside derby, the Sweden international leads the line against the Championship outfit this evening.
Giovanni Leoni is handed his Liverpool debut following his mid-August move from Parma, with the young Italian centre-back named alongside Joe Gomez, who makes a first start of the season.
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Andy Robertson captains the side at left-back with Jeremie Frimpong named on the right of the back four.
Giorgi Mamardashvili, the £29m summer signing from Valencia, is given his debut in lieu of Alisson Becker, who was present at Monday night's Ballon d'Or ceremony in Paris alongside club captain Virgil van Dijk.
Both players are absent from the squad tonight alongside Mohamed Salah and Florian Wirtz.
Federico Chiesa begins on the right side of the front three and Rio Ngumoha is given just his second start for the club after his 2024 switch from Chelsea.
The 17-year-old will fill on the left side to support Isak and Chiesa in the front three.
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In midfield, Wataru Endo and Curtis Jones are joined by teenager Trey Nyoni.
Hugo Ekitike and Milos Kerkez are on the bench alongside Kaide Gordon, Rhys Williams and Jayden Danns.
Liverpool: Mamardashvili; Frimpong, Leoni, Gomez, Robertson; Endo, Jones; Chiesa, Nyoni, Ngumoha; Isak.