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Palace are the only other side unbeaten in the league, winning two and drawing three, and have conceded just twice in the Premier League.The two clubs last met less than two months ago.
On that occasion, Palace emerged victorious on penalties in the Community Shield after twice coming from behind to secure a 2-2 draw after 90 minutes at Wembley.
Record signing Isak hadn't yet joined Liverpool when that match took place, and Arne Slot has to decide whether to hand the Swede a first league start for the club.
Here are Mirror Football's latest lines from around Anfield.
READ MORE:Furious Arne Slot’s private message to Hugo Ekitike as Liverpool boss left with decision to make
Alexander Isak has yet to complete a full 90 minutes for Liverpool since his summer move, with Arne Slot being careful with the striker after a limited pre-season.
Former Tottenham and Aston Villa boss Tim Sherwood was on punditry duty for the cup tie on Tuesday, and sympathised with the Liverpool manager while wondering aloud if Ekitike was impacted by the threat of Isak taking his spot.
"I think it's the pressure of Isak being there, the noise around it," Sherwood said.
Ekitike has let himself down."
Florian Wirtz would have been a better fit for Bayern Munich than for Liverpool, according to the Bavarian club's former striker Karl-Heinz Rummenigge.
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