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During the latter stages of the parade, a vehicle on Water Street in the city centre ploughed into supporters with reports of multiple injuries.
Police quickly cordoned off the area with emergency services on the scene and a nearby restaurant transforming into a makeshift Emergency Room.
It was later confirmed that an individual had been arrested with Counter Terrorism Policing North West now involved.
Here's everything we know about the incident at the time of writing...
At just before 6pm on May 26, police were made aware of reports of a Road Traffic Collision on Water Street in the Liverpool city centre.
The car stopped at the scene and a male detained."
Article continues belowMerseyside Police have confirmed a man has been arrested(Image: AFP via Getty Images)
Following their initial statement, the force subsequently confirmed that an arrest had been made.
“We would ask people not to speculate on the circumstances surrounding tonight’s incident on Water Street in Liverpool city centre," a second update read.
“We can confirm the man arrested is a 53-year-old white British man from the Liverpool area.
A further update from Merseyside Police is expected at 10.30pm on May 26.
Emergency services at the scene of the crash on Water Street(Image: PA)
The incident occurred on Water Street in Liverpool, near the Strand and was on the route of the parade, with the bus passing around 10 minutes before the incident.
Thank you, as ever, to the first responders for their professionalism and swift action.
"This is a difficult day for our city region, but we stand together."
At the time of writing there is no official figure on the number of injuries, with four ambulances, a fire engine and police cars at the scene.
A statement from the North West Air Ambulance Service (NWAS) reads: "NWAS is supporting an incident in Liverpool city centre, following reports of a road traffic collision.
"We are currently assessing the situation and working with other members of the emergency services.
And for much of the day that was the case before the terrifying incident.
A statement from the club read: "We are in direct contact with Merseyside Police regarding the incident on Water Street which happened towards the end of the trophy parade earlier this evening.