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Conor Bradley, Darwin Nunez and Cody Gakpo all found the target as the Premier League champions earned a 3-1 triumph at the Championship side, for whom Liam Lindsay notched a late strike.
The game was the first played by the Reds since the tragic passing of Diogo Jota, who died along with his brother Andre Silva in a road traffic accident in Spain last week.
The ECHO was in attendance at Deepdale and here we run the rule over the Liverpool players, including a number of new signings.
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In right place to score opener.
Joe Gomez
Welcome first action since limping off at Plymouth Argyle back in February, and distributed ball well.
Luca Stephenson
Playing out of position at centre-back, clearly benefited from season on loan at Dundee United and applied himself confidently.
Kostas Tsimikas
Couple of defensive interventions during opening stages at far post and looked to release Ngumoha whenever possible.
Trey Nyoni
In a deeper midfield role, appears to have developed physically and not averse to getting stuck in.
Ryan Gravenberch
One turn and pass in the first half prompted purrs from the Deepdale crowd and covered the turf well.
Mohamed Salah
Got through a lot of work and always a threat, often being double-marked by Preston defenders.
Dominik Szoboszlai
Had one strong shot blocked and almost on the end of a number of moves, and inadvertent assist for opener.
Rio Ngumoha
Extremely lively whenever in possession and willing to run at his marker, resulting in a number of shots and a part in initiating Bradley’s goal.
Liverpool's most prominent player.
Federico Chiesa
Too slow when handed chance to break first half before shooting wide, but did very well to help fashion first goal.
Freddie Woodman (for Mamardashvili 46)
Relentlessly teased by fans of his former club whenever the ball was at his feet, but dealt with it well for the most part.
Jeremie Frimpong (for Bradley 46)
A couple of chances to show his pace on debut and one good piece of covering defending.
Amara Nallo (for Stephenson 46)
Understandably a little uncertain given his brief most recent first-team experience but eventually settled.
Andy Robertson (for Gomez 46)
Employed as a makeshift centre-back, was caught out by one Preston attack but otherwise steady enough.
Milos Kerkez (for Tsimikas 46)
The new signing contributed at both ends down the left flank, and appears solid in the tackle.
Wataru Endo (for Gravenberch 46)
Wowed the crowd by keeping the ball brilliantly in a tight midfield space and later had a shot blocked from close range
Typically tenacious.
Curtis Jones (for Nyoni 46)
Neat and tidy in moving on possession and another to have a shot denied.
Ben Doak (for Salah 46)
Got away from his marker with one neat turn and later claimed a penalty when challenged inside the area
Crossed for the third goal.
Lewis Koumas (for Szoboszlai 46)
Quite happy to put his head down and run at the opposition.
Cody Gakpo (for Ngumoha 46)
Saw plenty of the ball down the left and had one shot saved
Lively showing ending with the well-taken third goal.
Darwin Nunez (for Chiesa 46)
Alert to intercept a poor backpass and tuck away the second before two trademark Jota celebrations in tribute to the Portuguese