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But the Reds hung on to triumph 2-1 at Anfield and secure their spot in Wednesday night's draw.Alexander Isak had earlier scored his first Liverpool goal before half-time but his opener was cancelled out by Shea Charles late on in the 76th minute.
Just as Southampton hope of a cup upset grew, Ekitike tapped in from a Federico Chiesa square ball with just four minutes to play before receiving his marching orders for a second yellow card.
Brilliant long ball set Chiesa through on goal when Ekitike scored.
Wataru Endo - 5
Typically combative to snap into tackles opposing players and used the ball well.
Good work to set up the first-minute Isak chance and floated across the pitch to regularly pick up the ball and set Liverpool away on the attack.
Federico Chiesa - 8
The kind of performance he needed.
Forced a good save from McCarthy with a low shot and brilliant to win the ball back and find Isak for his goal.
Subbed at half-time after a warmdown on the pitch.
Substitutes
Hugo Ekitike (Isak 46) - 6
Some beautiful touches and just looked so sharp.