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Arne Slot could consider up to three changes from the Liverpool team that edged past Burnley at the weekend as they kick off their Champions League campaign on Wednesday.
Liverpool will take on Atletico Madrid in the first of eight group phase games in the elite European competition this season, starting at home against a tough Diego Simeone side.
Slot's squad have maintained a perfect start to their Premier League campaign with a last-minute penalty win over newly-promoted Burnley on Sunday.
The Reds looked to be retreating to their first points dropped at the weekend, before Jeremie Frimpong's angled cross struck Hannibal's arm, leading to an anxious wait and eventual penalty decision.
Mohamed Salah stepped up and sent Martin Dubravka the wrong way, winning the game in the 95th minute to maintain Liverpool's unbeaten start to the season.
Meanwhile, Simeone's side secured their first three points of the season on Saturday with a 2-0 win over fellow Champions League stars Villarreal, after drawing two and losing one of their first three La Liga games this campaign.
The Spanish side will be hoping that their European journey gets off to a better start, but Slot's undefeated side stands menacingly in their way.
However, the Reds have been relying on some last-minute heroics lately, with two of their last four Premier League games being won with a strike in added time.
Given Robertson's sheer volume of games played in the Champions League so far, the Reds boss may opt for experience over youth in Europe.
However, Robertson has come to the defence of the £40million man, claiming that Kerkez is "only young" and is "the future of the club".
Isak isn't likely to make the start against Atletico, but could come off the bench - and Wirtz may see himself relegated to the sidelines for the in-form Hungarian in the middle of the park.
Liverpool predicted starting XI vs Atletico Madrid
(4-2-3-1) Alisson; Frimpong; Konate; Van Dijk; Robertson; Gravenberch; Mac Allister; Salah; Szoboszlai; Gakpo; Ekitike.