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If all the eggs are having to be placed into the one basket for Liverpool just now then you would argue the Premier League still supersedes the Europa League.
Sunday's 1-0 defeat to Crystal Palace might have handed the initiative to Manchester City, who now hold a two-point advantage over both the Reds and Arsenal, but it is far from insurmountable with six games left to negotiate.
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Liverpool scored five times without reply on their most recent visit to Bergamo four years ago and with a place in the semi-final at stake, there will be no throwing in of the towel just yet.
That being said, the precarious nature of the title challenge means this is a particularly delicate one for Klopp to try and get right, particularly given the lack of form of so many of his key men just now.
As Liverpool's most creative outlet, Trent-Alexander Arnold will be needed in a game where the Reds need three goals just to force extra time.
And while the defender has been absent for most of the calendar year with injury issues, this feels like a good time to hoist him back into the thick of it.
One or two passes from that gifted right peg might just be enough to unlock the Serie A side and with Conor Bradley likely to be sidelined anyway through injury, this one is a no-brainer.
Ryan Gravenberch feels like he would represent more of a gamble at this stage, however, that is not doing the Netherlands Under-21 star a disservice.
Up top, Klopp has his five-man frontline available to him for the three designated spots and while that quintet have registered 82 goals between them, few have come of late.
This feels like an opportune time to recall Diogo Jota to try and shake off some of the rust that accumulated during his two-month absence after the victory against Brentford in mid-February.
A fully-fit Jota can still contribute hugely but he must start somewhere.
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