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The Reds return to Anfield three days on from their Merseyside 2-1 derby success over Everton in the Premier League.Goals from Ryan Gravenberch and Hugo Ekitike were enough to get the defending champions over the line and preserve their perfect start to the league season.
Head coach Arne Slot has already confirmed that there will be a number of changes to the team for the third-round tie against the Saints.
The Dutchman relied on similar rotation last season, although Liverpool still did make it to the final of the competition.
They were denied a win at Wembley against Newcastle United, with Alexander Isak netting the winner.
The Swede is now in Liverpool colours and could be in contention to make his second start for the club since his record-breaking switch to Merseyside.
As for Southampton?
They have struggled since their relegation from the Premier League last season and sit in 19th in the second tier.
New head coach Will Still won his first game in charge, although the Saints are now on a five-match run without a victory.
Stick with us for build-up, goal updates and reaction as the Reds look to make progress In another competition.