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It's expected to be another competitive encounter, less than three months since a 1-1 draw between the two teams at Anfield on the final day of last season.
And Slot's team might look a whole lot different compared to the XI that lined up last time out against Palace.
Jeremie Frimpong, Florian Wirtz, Milos Kerkez, Armin Pecsi, Freddie Woodman and Giorgi Mamardashvili are the others that have signed for the Reds.
Taking the new faces, including Ekitike, into consideration, what does Slot's best XI look like ahead of the Community Shield against Palace?
Here, the ECHO takes a look at his best team...
Although Mamardashvili is expected to push for the No.1 shirt this season, Alisson Becker is still Liverpool's best goalkeeper and he would keep the shirt.
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Moving to the back-line and change is no doubt expected.
Bradley, however, would just get the nod due to his superior defensive capabilities.
As for the central defensive pairing, Virgil van Dijk and Ibrahima Konate remain Liverpool's best in that position.
Ryan Gravenberch and Alexis Mac Allister make up the deeper roles in Slot's best XI, with Wirtz coming in as the No.10 following his blockbuster £100m plus add-ons arrival from Bayer Leverkusen last month.
That would leave Dominik Szoboszlai, Curtis Jones and Wataru Endo as back-up, with Harvey Elliott expected to leave the Reds in search of more game time.
It's a strong-looking midfield department and one that Slot should be delighted about heading into the new season.
Last but not least, Slot's best forward line would contain Mohamed Salah, Ekitike and Cody Gakpo.