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This follows an approach from Liverpool, who has indicated its willingness to part with a British-record £120 million ($161.2 million) for the Swedish player.
Newcastle's response was to declare that Isak is not on the market, leading Liverpool to swiftly shift its attention to Hugo Ekitike, another player on Newcastle's radar.
While manager Eddie Howe remains confident that his star player will stay put, Newcastle is formulating backup plans that could trigger a domino effect in the Premier League.
A report from the Daily Mail has disclosed the four strikers that Newcastle are currently researching: Nicolas Jackson, Ollie Watkins, Yoane Wissa, and Benjamin Sesko.
Howe's club has already tabled an offer for Wissa, which Brentford promptly turned down, while Watkins and Jackson are also on Manchester United's radar?
Ollie Watkins is on Newcastle's radar.
Benjamin Sesko was in discussions to join Arsenal before the Gunners ultimately opted for Viktor Gyokeres, whose transfer was confirmed on Saturday.
Wissa, who netted 19 times for Brentford last season, is keen to move on with just a year left on his contract
Conversely, Sesko is considered a valuable asset by RB Leipzig, who are likely to demand around £70 million ($94.1 million)
Howe faced numerous questions about Isak's future during a press conference in Singapore on Saturday
When asked if the Liverpool target would stay, Howe responded: "I said after the Celtic game, I certainly hope he stays, and I said I was confident he would stay.
"I don't see anything that will change that opinion of mine at the moment - but it's football and who knows what the future may bring
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