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But you'd still expect the likes of Mohamed Salah to return to the line-up, now with a point to prove.
Rotation in one form or another has been effectively forced on Liverpool, with this game coming amid an intense run even by Premier League standards.
The Reds travelled to Italy last Thursday, and will have played two league matches before even a week has passed, before going down to London for a Saturday lunchtime kick-off against West Ham (the Rúben Amorim derby?).
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Manchester City boss Pep Guardiola called out the schedule recently, complaining that the FA Cup semi-final on Saturday came too hot on the heels of Wednesday night Champions League action.
After that, Liverpool will also have the chance to go four points clear of Manchester City if it can win the Merseyside derby.
Manchester City is finally back in league action on Thursday, when it travels to Brighton.
That's a potentially difficult fixture, not least if both of its rivals have further piled on the pressure.
And it will be some time before Manchester City makes up its second game in hand.
The fixture scheduling has been made a little easier by virtue of Guardiola's European exit, but the extra fixture still won't be permanently made up until the penultimate game of the Premier League season.
Ahead of hosting West Ham on the final day (Liverpool once again has Wolves), Manchester City faces a Tuesday night trip to Spurs.
But Manchester City won't love the fact that its second game in hand is not made up until so late in the season, especially with it being a potentially tricky fixture.
It only takes on relevance if Liverpool can keep up the pressure, though.
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