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Real Madrid have confirmed Trent Alexander-Arnold has been diagnosed with a muscle injury to the biceps femoris in his left leg.
The Spanish club will clarify how long this will sideline the former Liverpool full-back, with a match between the two clubs on the horizon.
Alexander-Arnold was making his Champions League debut for the team he joined this summer, having chosen not to extend his contract with boyhood club Liverpool.
It read: "Following tests carried out today by the Real Madrid Medical Services on our player, Trent Alexander-Arnold, he has been diagnosed with a muscle injury to the biceps femoris in his left leg.
Former Liverpool player Trent Alexander-Arnold has responded to his latest injury setback.
Liverpool are due to play Real in the fourth round of Champions League league phase fixtures
[Eduardo] Camavinga and Jude [Bellingham] are back and will be able to play on Saturday (against Espanyol)."
Alonso may be forced to be 'creative' against Liverpool in early November too if Alexander-Arnold's injury proves to be long-term and Dani Carvajal is handed an extended Champions League suspension.
The 33-year-old replaced the former Reds vice-captain following his injury on Tuesday night but was unable to complete the rest of the match before being sent off