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Trent Alexander-Arnold suffered a nightmare Champions League debut for Real Madrid, coming off injured after just five minutes.
Alexander-Arnold, who'd only started two of Madrid's opening four games in La Liga, felt his hamstring in the early stages of their clash with Marseille on Tuesday.
His participation in the game against his former side, Liverpool, in the Champions League in less than two months is now in real danger.
Both teams will be hoping to qualify for the knockout stages automatically, with Liverpool having topped the league phase last season.
There were two minutes and 40 seconds on the clock at the Bernabeu when Alexander-Arnold played a pass and immediately felt his left hamstring.
The defender subsequently sat down on the turf, signalling for treatment from Madrid's medical staff.
It soon became apparent that Alexander-Arnold wouldn't be able to continue Los Blancos' Champions League opener.
The 26-year-old was replaced by Dani Carvajal, who started Saturday's 2-1 win away to Real Sociedad as Madrid continued their perfect start to the season.
Alexander-Arnold's injury could also hurt his chances of playing for England during the October and November international breaks.
The ex-Liverpool star missed out on Thomas Tuchel's squad earlier this month in what was arguably the England manager's biggest call.
On his decision not to hand Alexander-Arnold or Everton loanee Jack Grealish a call-up, Tuchel explained: "There's no doubt I am a big fan of Trent and Jack Grealish.
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