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Slot, who said Isak was "maybe the best striker in the world", asked for fans to be patient with him if the 25-year-old was taken off or not brought on until late on as he tries to get him up to speed.
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He missed a proper pre-season," said the Dutchman.
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Slot said: "I spoke to him by phone after he signed because he had to go to the national team and 99 out of 100 times I leave them for the manager they are working with over there.
I faced him a few times and know what a quality player he is."
"Of course he wasn’t happy with that but I think he understood my arguments," said the Reds boss of the Italian.
"I think he also showed it as he wasn’t selected but worked really hard in these days to be ready for the upcoming games and that is even more important than what a player tells you."