Slot: Isak could make debut vs Atletico - but he won't play 90 minutes
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Asked about Isak's chance of playing against Atletico, Slot said: "There is definitely a chance because he is in the squad.
"Then there's a chance to play, but I can say it's 100 per cent sure that he will not play 90 minutes.
But he's part of the squad.
"It's already a Champions League game to look forward to, but if people look forward to his playing time, that could mean that could happen as well."
Questioned on whether Isak will start, Slot replied: "The only thing that is sure is that he will not play 90 and all the rest you will see."
Also See:Slot: Isak's biggest challenge is getting fit
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Isak missed pre-season and game time due to his dispute with Newcastle before sealing his move to Liverpool, and he has only played 18 minutes of football this season for Sweden.
Asked what Isak's biggest challenge is, Slot responded: "Getting fit after missing out on four months of proper team sessions.
"He doesn't have to prove to anyone that he's good enough to play in the Premier League because that's what he's proven already at Newcastle.
"The main challenge he has is to become so fit that he is first of all ready to do what he did last season."
He added: "The moment he's fit, match fit, and he can play 90, then the next step is playing three times in a week, then the next step is going one step further in terms of pressing.
Liverpool captain Virgil van Dijk believes Isak, who scored 54 times in 86 Premier League appearances for Newcastle, is the "complete striker".
"He's a clinical finisher," he said.
Van Dijk, however, is aware that the British-record £125m fee paid for Isak will "create pressure" for the 25-year-old.
The Dutchman said: "It's not really an addition is it
Just work hard, enjoy being the number nine for Liverpool, be important for the group with goals, assists, link-up play, help others and that's the only thing you have influence on."
Van Dijk also echoed his head coach's calls for Isak to get match fit.
Asked about his first impressions of Isak, he replied: "Very good