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The Reds can strengthen their position as Premier League leaders, whilst the Blues have the opportunity to move within two points of their fierce rivals.Arne Slot's side won their first four matches of the Premier League campaign as well as their Champions League opener vs Atletico Madrid with one theme in common - they all required late winners.
After losing their season opener, David Moyes has overseen two wins and one draw to sit just outside of the top-four places.
READ MORE:Alexis Mac Allister takes swipe over Alexander Isak's transfer after Liverpool's lengthy sagaREAD MORE:Arne Slot pays tribute to Everton for Liverpool support after Diogo Jota death
Therefore alongside the bragging rights that come from winning the Merseyside derby, both teams have desires to maintain their early season form.
Ahead of the showdown, there have been injuries or fitness doubts in both camps to be aware of.
The big one for the hosts is Alexander Isak, who made his first appearance when starting on Wednesday night against Atletico.
"We had recovery yesterday, we're going to train this afternoon.
"So first of all we have to see how they all feel.
What I do know is that Alex did feel his body more maybe than ever before after the 60 minutes he played.
"So let’s see how he’s recovered today and then we’ll think about the line-up, mainly today, and you will hear it tomorrow."
Last weekend's fixture against Burnley acts as evidence Slot is ready to leave out his record signing should it be deemed necessary for long-term gain.
Mykolenko, on the other hand, had returned from the problem that had kept him out of the opening two matches of the season.
The defender returned for matches against Mansfield Town and Wolverhampton Wanderers but was forced to withdraw from international duty earlier this month, then missed last weekend's goalless draw at home to Aston Villa.
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Sky has slashed the price of its Essential TV and Sky Sports bundle for the 2025/26 season, saving members £336 and offering more than 1,400 live matches across the Premier League, EFL and more.
Sky will show at least 215 live Premier League games this season, an increase of up to 100 more.