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The couple grew up on the same estate in Croxteth, but the Merseyside derby divides their families, as the Rooneys are all Evertonians, with the McLoughlins - Coleen's family - being Reds.Rooney joined his boyhood club aged nine and spent almost a decade there before signing for Manchester United.
He then spent 13 seasons at Old Trafford before briefly returning to Goodison Park for 12 months.
Rooney has reflected on his two stints at Everton before the derby this weekend.
That included recalling a story about his wife, Coleen, from five years ago.
He will not be at Anfield, as the pundit is spending Saturday at MediaCity in Salford before being on Match of the Day later that evening.
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"I'll be watching the derby at the BBC studios, but there'll be family and friends going," he said on Friday's episode of The Wayne Rooney Show.
"All my family are Evertonians and all Coleen's family are Liverpudlians."
Rooney acknowledged that the dynamic wasn't an issue while he was playing, but did recall that one of Coleen's brothers refused to watch him play for United in the 2008 Champions League final.
"He said to me: 'I want you to do well, but I couldn't bear being at the stadium watching Man United lift the Champions League if you win it', so he didn't go."
He then shared another story, this time about Coleen.
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