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He could replace the profligate Darwin Nunez who struggled in the first leg against Atalanta, with Luis Diaz and Mohamed Salah keeping their places out wide.
Diogo Jota has looked rusty since his return and while he is Liverpool's most predatory finisher, him and Nunez might be used as second-half options instead.
While he is not as capable as a fully-fit Endo at fending off counter-attacks, he is excellent on the ball and him playing him deeper would allow for the energy of Szoboszlai and Harvey Elliott in the two No6
8 roles.
Liverpool were thwarted in the first leg when Elliott played at right wing.
But in midfield, he and Szoboszlai can provide the running on and off the ball to trouble Atalanta's man-marking system.
Gakpo can also drop deep from centre-forward to ensure Liverpool are not as easily overrun as they were in the first leg.
Liverpool's travelling squad means Jayden Danns and Bobby Clark offer wildcard options from the reserves if the senior players struggle against the Serie A side like last week.
A clean sheet will be the first target for the Merseyside club, and another will be to be far more clinical than in their past three games of which an xG of 9.08 led to just two goals.
Possible Liverpool starting XI vs Atalanta: Alisson; Alexander-Arnold, Quansah, Van Dijk, Robertson; Mac Allister, Elliott, Szoboszlai; Salah, Gakpo, Diaz
Liverpool travelling squad in full: Alisson, Gomez, Endo, Van Dijk, Konate, Diaz, Szoboszlai, Nunez, Mac Allister, Salah, Adrian, Jones, Gakpo, Elliott, Jota, Tsimikas, Robertson, Gravenberch, Clark, McConnell, Kelleher, Alexander-Arnold, Danns, Quansah.
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