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Wednesday's 1-0 loss against Bournemouth extended Wolves' winless run in the league to six matches and Gary O'Neil makes three changes from that defeat.
Santiago Bueno misses out after suffering a hamstring injury against the Cherries with Tommy Doyle and Pablo Sarabia dropping to the bench.
Matt Doherty, Boubacar Traore and Matheus Cunha are the trio to come in.
Wolves XI: Sa, Doherty, Kilman, T.
Gomes, Lemina, Ait-Nouri, Cunha, Hwang.
Subs: Bentley, H.
Bueno, Doyle, Sarabia, Gonzalez, Barnett, Okoduwa, Chirewa, Fraser.
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Luton are looking to bounce back after successive 5-1 losses, most recently against Brentford on Saturday, and Rob Edwards makes one change for the trip to Molineux.
Daiki Hashioka comes in for Manchester City loanee Issa Kabore, who has been ruled out for the rest of the season after picking up an ankle injury against Brentford.
Elijah Adebayo is named on the bench after missing the last 12 games with a thigh injury.
Luton XI: Kaminski, Burke, Mengi, Osho, Hashioka, Lokonga, Barkley, Doughty, Clark, Chong, Morris.
Subs: Shea, Krul, Berry, Woodrow, Adebayo, Mpanzu, Townsend, Onyedinma, Johnson.
BBC SportCopyright: BBC Sport
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